BIOMOD JAPAN 2018
BIOMOD (International Bio-molecular Design Competition) は，大学生が生体分子をナノスケールで制御するための技術を習得し，その成果を競う国際競技会です． 学生達はチームを構成し，夏の期間に生体分子からなるシステムを設計，構築，解析する必要があります．競技会では，生体分子ロボット，生体分子による論理演算や計算，構造ナノバイオテクノロジーなどの分野に焦点をあてていますが，これらの分野のみに限定はしていません．2018年大会(Jamboree)は，カリフォルニア大学サンフランシスコ校にて１０月２７日から開催され、参加チームは研究成果に関する10分のプレゼンテーションを英語で行います．さらに，各チームは，成果の概要をまとめた3分間のYoutubeビデオと，実施したプロジェクトの目的，データ，結果の詳細を記述したwebページを期限までに提出することが要求されます．これらの提出物とプレゼンテーションを評価することによって，賞が決定されます．
◆BIOMOD JAPAN2018 プログラム
13:30-13:50 プレゼン2 （東京大学）
14:20-14:40 プレゼン4 （九州工業大学）
14:40-15:00 プレゼン5 （関西大学）
Season (Ocean University of China)
Chinese Characters in “DNA Library”
DNA has the advantages of high storage density and long storage time, and can be used as a good information storage carrier. In recent years, the practice of storing substances or information into DNA sequences has become more and more popular among researchers, DNA storage has therefore become a research hotspot. However, existing DNA storage has not yet covered the field of Chinese characters’ storage. Therefore, based on the structural characteristics of Chinese characters, we use the concept of roots in the “five-stroke input method”, and at the same time, combined with the idea of “split” of Chinese characters, we designed a set of DNA coding schemes suitable for Chinese characters’ storage, which can achieve the DNA storage of Chinese characters that are complex in fonts and heavy in number. Meanwhile, the DNA storage of huge Chinese characters provides coding ideas for DNA storage of the same type of characters.
Team Handai (Osaka University)
Get together!! DNA swarm robots
Swarm robotics is a new field of engineering in which robots are directed to synchronize through algorithm. In this research, DNA origami is utilized to create robots that can gather and have a specific function such as detection of a certain ligand. 2 types of robot will be attempted, activator and effector. By activating the activator through a certain ligand, pathways will be opened to let the effector attach to the activators and creating a swarm of robots at the ligand position. The extent of the feasibility in this experiment is to firstly produce a robot that can firstly aggregate through strand replacement mechanism before proceeding to use other mechanism such as aptamers to enable detection of ligand in the environment.
YOKABIO (Kyushu Institue of Technology)
As a problem in current cancer treatments, healthy cells other than cancer cellsare also adversely affected, so various side effects appear. In recent years,researchers are developing Drug Delivery System(DDS) that transport drugsdirectly to cancer cells using nanoscale structures made of biomolecules. Thereare many merits by using this technology, but due to the difficulty of its control,it is not a practical level at present.We propose a new cancer treatment method focusing on energy for cell’s lifeactivity. Our proposed DNA system covers a wide range of cells like conventionalcancer treatment. However, this will cause only cancer cells to die, normal cellswill hardly be affected. We believe that our research will become a foothold for thefuture development of cancer treatment.
UT-Komaba (The University of Tokyo)
It is known that we can trap particles using DNA hydrogels. We developed a system that can wrap a target and then collect it using DNA hydrogels.
To achieve this, we developed a system that sorts target in two phases; captureing and collecting. We prepared DNA strands that grew from a same particle. The DNA strands had a linker region and a shrinking unit.
First, we captured the target by wrapping the target using a DNA hydrogel. The hydrogel was then captured by an arm made of DNA strands that could bind to DNA hydrogel on thier linker regions.
Next, the arms shrank by the shrinking unit so that the hydrogel was collected to the particle.
This system can be applied to a man-made immune system by selectively capturing targets and collecting them to one voluntary point, detoxifying bacteria or foreign substances.
Team Kansai (Kansai University)
Nano QR code Ver.2
We retry to make QR code using DNA origami method this time. Our team previously tried to make QR code using DNA origami method, in BIOMOD 2014. By using the dumbbell hairpin for the QR code dots, the DNA origami structure was expressed with a height difference. Therefore three DNA origami structures were required due to the position of the dumbbell hairpin in order to produce QR code. However, it was difficult to bond due to repulsion among DNA origami structures, and QR code could not be expressed. Then, we will reconsider the position of dumbbell hairpins and express the QR code with one DNA origami structure. We read QR code of DNA origami structures from AFM images using the camera application. Then if we can say that we succeeded in developing the smallest information medium in the world.
Team Sendai (Tohoku University)
“Miura Folding” is a pattern composed of repeated parallelograms which can “transform” and “fold” (“transfold”) as a whole in unison. Here, we designed a planar transfoldable DNA origami based on the Miura Folding. Our designed structure is composed of multiple parallelogram panels made of double stranded DNA. The panels are connected by flexible single-stranded “hinge DNA” at the edges. In addition, a separate set of “actuator DNA” are attached to arbitrary edges, maintaining the closed state of the structure. To open the structure, signal DNA are inserted to form rigid double strands with the actuator DNA, holding the panels open. With this design, individual units can mediate reactions to perform dynamic transfolding as a whole. Furthermore, by repeating the designed structures, large signal-reacting nanostructures can be formed. In the future, this design may be applied to form reconstructable capsids and to add transformability to self-assembled products.
- News Letter No.21
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